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scr [2017-10-15 18:15:15]
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scr [2017-10-15 18:15:15]

4.5 S RNA, causes RNA-driven elongation arrest by interaction with the 23S rRNA
locus
BSU_misc_RNA_2
pI
0.00
mw
0.00 kDa
function
presecretory protein translocation
product
small cytoplasmic RNA (scRNA, 4.5S RNA)
essential
yes
synonyms
Outlinks
KEGGBsubCycSubtiListExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.5|Protein secretion]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • [category|SW 6|Groups of genes] → [category|SW 6.9|NcRNA] → [category|SW 6.9.3|Small cytoplasmatic RNA]

    • Gene

    Coordinates
    26,533 → 26,635

    Phenotypes of a mutant

  • the gene is essential [Pubmed|7506707]

    • The protein

    Structure

  • [PDB|4UE4] (complex [protein|EC025F78D0BCBD91162BAAB9EAB7D3837E0A3208|Ffh]-[protein|097C817A5A3E31F73F6ABC4AA95852A64E43A057|Scr] RNA) [Pubmed|26344568]

    • Expression and Regulation

    Operons

    genes
    [gene|5FC8D0B30B55C1CBC2CDE8E56E7E948A781EF2AB|yaaJ]-[gene|097C817A5A3E31F73F6ABC4AA95852A64E43A057|scr]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, (both promoters), in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]
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    additional information

  • the mature 5' end of the RNA is generated by [protein|BAB297D18F94FFA67B8D12A684AB4D1BCDFB4981|RNase III]-mediated cleavage at 38 nts [pubmed|26883633]
  • the mature 3' end of the RNA is generated by [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y]-mediated cleavage at 320 nts, and further trimming to 308 nts [pubmed|26883633]

    • References

    Reviews

  • 25212246,27890920

    • Original publications

  • 9346318,2468993,17576666,1372600,7506707,1383945,7538759,10224127,9677377,8662730,10222262,25270875,25402410,26344568,26883633

    • Labs working on this gene/RNA

  • [SW|David Bechhofer], Mount Sinai School, New York, USA [http://www.mountsinai.org/Research/Centers Laboratories and Programs/Bechhofer Laboratory?citype=Physician&ciid=Bechhofer David H 1255565 Homepage]